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董旻岳主任醫師

浙江大學醫學院附屬婦產科醫院實驗室

執業經歷

1985年畢業于浙江醫科大學醫學系，2000-2001年在美國伊利諾依大學芝加哥分校(UIC)醫學院從事生殖生理學研究。研究領域為生殖醫學、圍產醫學和生殖遺傳學，主要研究方向為妊娠免疫耐受機制、生殖和妊娠相關疾病的免疫學病因與發病機制，以及遺傳性出生缺陷的防控研究。主持、承擔國家自然科學基金、973項目子課題等課題多項。發表學術論文百余篇，主要論文均發表在SCI刊物，獲國家科技進步獎二等獎、浙江省科技進步一等獎等科技成果獎勵6項。研究方向：生殖醫學、圍產醫學主要在研課題： 1. Follistatin-like 3對滋養細胞與胚胎的影響以及在妊娠并發癥中的作用。2013年國家自然科學基金(課題負責人) 2. 子宮內膜細胞脂肪酸結合蛋白4在胚胎著床中的作用與機制研究。2011年國家自然科學基金(課題負責人) 3. 輔助生殖誘發胚胎源性疾病的風險評估和機制研究。2011年國家重大科學研究計劃(973)項目(學術骨干) 4. Toll樣受體7、8介導的炎性反應通路在滋養細胞阻止乙型肝炎病毒宮內傳播中的作用。2010年浙江省自然科學基金(課題負責人) 近五年成果獲獎： 1. 提高出生人口質量的生殖技術創建、體系優化與臨床推廣應用：2010年國家科技進步二等獎; 2. 阻斷出生缺陷、促進子代健康關鍵技術體系的創建與推廣應用：2010年浙江省科技進步一等獎; 近五年發表的代表性論文(*為通訊作者)： 1. He J, Zhang AP, Fang M, Fang R, Ge JM, Jiang Y, Zhang H, Han C, Ye XQ, Yu DQ, Huang HF, Liu Y*, Dong MY*. Methylation levels at IGF2 and GNAS DMRs in infants born to preeclamptic pregnancies. BMC Genomics, 2013, 14:472. 2. Zhou QY, Li J, Wang HZ, Han C, Tian T, Zhu QY, Huang HF, Dong MY*. Serum preadipocyte factor-1 is increased in fetuses of pregnancy complicated with severe preeclampsia. Clinica Chimica Acta, 2013, 424:212-215. 3. Guo J, Tian T, Lu DH, Xia GY, Wang HZ, Dong MY*. Alterations of maternal serum and placental follistatin-like 3 and myostatin in pre-eclampsia. J Obstet Gynecol Res, 2012 Jul, 38( 7):988-996. 4. Hu DX, Tian T, Guo J, Wang HZ, Chen DQ, Dong MY*. Decreased maternal and placental concentrations of follistatin-like 3 in gestational diabetes. Clinica Chimica Acta, 2012, 413: 533-536. 5. Yin LJ, Zhang Y, Lv, PP, He WH, Wu YT, Liu AX, Ding GL, Dong MY, Qu F, Xu CM, Zhu XM, Huang HF. Insufficient maintenance DNA methylation is associated with abnormal embryonic development. BMC Med. 2012;10:26. 6. Liu FJ, Guo J, Tian T, Wang HZ, Dong FY, Huang HF, Dong MY*. Placental trophoblasts shifted Th1 ? Th2 balance toward Th2 and inhibited Th17 immunity at fetomaternal interface. APMIS, 2011, 119: 597–604. 7. Wang N, Wang, LY, Le F, Zhan QT, Zheng YM, Ding GL, Chen XJ, Sheng JZ, Dong MY, Huang HF, Jin F. Altered expression of Armet and Mrlp51 in the oocyte, preimplantation embryo, and brain of mice following oocyte in vitro maturation but postnatal brain development and cognitive function are normal. Reproduction, 2011,142( 3):401-408. 8. Chen D, Xia G, Xu P, Dong MY*. Peripartum serum leptin and soluble leptin receptor levels in women with gestational diabetes. Acta Obstet Gynecol Scand. 2010, 89(12): 1595- 1599. 9. Zhang K, He J, Dong MY*. Relationship between umbilical artery Doppler waveform analysis and perinatal prognosis in women with intrahepatic cholestasis of pregnancy. Int J Gynaecol Obstet. 2010;111(2):187-8. 10. Wang TT, Wu YT, Dong MY, Sheng JZ Leung PC, Huang HF. G546A polymorphism of growth differentiation factor-9 contributes to the poor outcome of ovarian stimulation in women with diminished ovarian reserve. FERTILITY AND STERILITY. 2010; 94(6): 2490-2492. 11. Liang ZX, Dong MY, Cheng Q, Chen DQ. Gestational diabetes mellitus screening based on the gene chip technique. Diabetes Res Clin Pract, 2010 Aug, 89(2):167-73. 12. Qu F, Wang FF, Lu XE, Dong MY, Sheng JZ, Lv PP, Ding GL, Shi BW, Zhang D, Huang HF. Altered aquaporin expression in women with polycystic ovary syndrome: hyperandrogenism in follicular fluid inhibits aquaporin-9 in granulosa cells through the phosphatidylinositol 3-kinase pathway. HUMAN REPRODUCTION, JUN 2010, 25(6): 1441-1450 13. Ding GL, Chen XJ, Luo Q, Dong MY, Wang N, Huang HF. Attenuated oocyte fertilization and embryo development associated with altered growth factor/signal transduction induced by endometriotic peritoneal fluid. FERTILITY AND STERILITY, MAY 2010, 93(8): 2538-2544 14. Wei J, Wang HM, Yang XF, Dong MY, Wang ZP. Altered gene profile of placenta from women with intrahepatic cholestasis of pregnancy. Arch Gynecol Obstet, 2010 May, 281( 5): 801-10 15. Lou H, Ding W, Dong MY, Zhu Y, Zhou C, Wang Z, Yang X, Yao Q, Li D, Miao M. The Presence of Hepatitis B Surface Antigen in the Ova of Pregnant Women and Its Relationship with Intra-uterine Infection by Hepatitis B Virus. J Int Med Res, 2010, 38(1): 214-9 16. Tang L, Zhang Y, Pan H, Luo Q, Zhu XM, Dong MY, Leung PCK, Sheng JZ, Huang HF. Involvement of cyclin B1 in progesterone-mediated cell growth inhibition, G2/M cell cycle arrest, and apoptosis in human endometrial cell. Reprod Biol Endocrinol, 2009, 7: 17. Shangguan XJ, Liu FJ, Wang HZ, He J, Dong MY*. Alterations in serum adipocyte fatty acid binding protein and retinol binding protein-4 in normal pregnancy and preeclampsia. Clinica Chimica Acta, 2009, 407: 58-61 18. Chen DQ, Wang HZ, Huang HF, Dong MY*. Vascular Endothelial Growth Factor Attenuates Nω-Nitro-L-Arginine Methyl Ester-Induced Preeclampsia-Like Manifestations in Rats. Clinical and Experimental Hypertension. 2008 Oct, 30(7): 606- 615. 19. Chen X, Qian X, Chen H, Dong M*. Serum levels of nitric oxide metabolites during labour with or without combined spinal-epidural analgesia. EUROPEAN JOURNAL OF ANAESTHESIOLOGY. 2008 Sep, 25 (9): 708-713 20. Feng C, Wang LQ, Dong M, Huang HF. Need for standardization and confirmation of STS deletions on the Y chromosome – Reply. FERTILITY AND STERILITY. 2008 Aug, 90 (2): 464-464 21. Feng C, Wang LQ, Dong M*, Huang HF. Assisted reproductive technology may increase clinical mutation detection in male offspring. FERTILITY AND STERILITY, 2008 Jul, 90(1): 92-96. 22. Huang H, Dong M*. The effect of trohphoblasts on T lymphocytes and the role of indoamine 2,3-dioxigenase. Human Reproduction. 2007 Jul, 22 (Supl 1): 112-112 Meeting abstract O028. 23. Minyue Dong*, Guolian Ding, Jun Zhou, Hanzhi Wang,Yi Zhao, Hefeng Huang. The effect of trohphoblasts on T lymphocytes: Possible regulatory effector molecules--A proteomic analysis. Cellular Physiology and Biochemistry, 2008, 21:463-472. 24. Wensheng HU, Zhengping WANG，Hanzhi WANG, Hefeng HUANG and Minyue DONG*. Serum Visfatin Levels in Late Pregnancy and Preeclampsia. Acta Obstet Gynecol Scand, 2008 April, 87(4): 413-418. 25. Dongxiao Hu, Zhengping Wang, Wuwen Zhang, Hanzhi Wang, and Minyue Dong*. Alteration of Peripheral CD4+CD25+ Regulatory T Lymphocytes in Pregnancy and Preeclampsia. Acta Obstet Gynecol Scand, 2008, 87(2): 190-194. 26. Qingxia Meng, Huijuan Gao, Chengming Xu, Minyue Dong, Xia Sheng, Jiangzhong Sheng, Hefeng Huang. Reduced Expression and Function of Aquaporin-3 in Mouse Metaphase II Oocytes Induced by Controlled Ovarian Hyperstimulation Were Associated with Subsequent Low fertility Rate. Cell Physiol and Biochem, 2008; 21: 123-128.