葉楓副主任醫(yī)師
浙江大學(xué)醫(yī)學(xué)院附屬婦產(chǎn)科醫(yī)院實(shí)驗(yàn)室
[簡(jiǎn) 歷] 2005年畢業(yè)于浙江大學(xué)醫(yī)學(xué)院婦科腫瘤專業(yè)，獲博士學(xué)位。近年來(lái)一直從事婦科腫瘤的分子生物學(xué)發(fā)病機(jī)制的研究，在國(guó)內(nèi)外核心學(xué)術(shù)期刊上發(fā)表論文三十余篇。參與婦女生殖與健康重點(diǎn)實(shí)驗(yàn)室的建設(shè)，指導(dǎo)研究生從事婦科惡性腫瘤的分子生物學(xué)基礎(chǔ)研究。 研究方向： 1、婦科腫瘤 2、分子腫瘤學(xué) 承擔(dān)科研項(xiàng)目： 1.siRNA表觀遺傳學(xué)上調(diào)控宮頸癌HPV16癌基因表達(dá)分子靶點(diǎn)。高等學(xué)校博士學(xué)科點(diǎn)專項(xiàng)科研基金，2008.1-2010.12，排名1/9 2.染色體11q22-q25區(qū)候選抑癌基因高甲基化和宮頸癌的發(fā)生機(jī)制，浙江省自然基金(Y205190)，2006.1-2008.12，排名：1/7 3.喜樹(shù)堿對(duì)耐紫杉醇卵巢癌細(xì)胞的作用機(jī)制研究，浙江省中醫(yī)藥局(2006C089)，2006.1-2007.12，排名：1/7 4.Notch蛋白及其靶基因Hes1、Hes5在宮頸癌細(xì)胞分化中作用的研究，浙江省衛(wèi)生廳青年項(xiàng)目(2006QN018)，2006.7-2008.12，排名：1/4 5.抑癌基因啟動(dòng)子CpG島高甲基化與宮頸癌發(fā)生, 浙江省教育廳( 20050971), 2005.7- 2006.12，排名1/6 6.卵巢癌腫瘤干細(xì)胞的分離、鑒定及其在化療耐藥中的分子機(jī)制。浙江省衛(wèi)生廳面上項(xiàng)目(2007A129)，2007.7- 2009.12，排名1/8 代表性論著： (1)Ye F, Chen HZ, Xie X, Ye DF, Lu WG, Ding ZM. Vascular endothelial growth factor (VEGF) and ovarian carcinoma cell supernatant activate signal transducers and activators of transcription (STATs) via VEGF receptor-2 (KDR) in human hemopoietic progenitor cells. Gynecol Oncol. 2004 Jul;94(1):125-33. (2)Ye F, Chen HZ, Xie X, Ye DF, Lu WG. Ovarian carcinoma cells effectively inhibit differentiation and maturation of dendritic cells derived from hematopoietic progenitor cells in vitro. Cancer Invest. 2005;23(5):379-85. (3)Ye F, Chen HZ, Liang ZX, Lu WG, Cheng Q, Xie X. Establishment of Cervical Cancer Model via Inoculating SiHa Cells into Humanized Severe Combined Immunodeficient Mice. Eur J Gynaecol Oncol. 2006;27(6):566-72. (4)Ye F, Zhang SF, Xie X, Lu WG. OPCML Gene Promoter Methylation and Gene Expression in Tumor and Stroma Cells of Invasive Cervical Carcinoma. Cancer Invest. 2008, accepted. (5)Huang J, Ye F, Chen H, Lu W, Xie X. Amino acid substitution polymorphisms of the DNA repair gene MGMT and the susceptibility to cervical carcinoma. Carcinogenesis. 2007 Jun;28(6):1314-22. Epub 2007 Jan 18. (6)Huang J, Ye F, Chen H, Lu W, Xie X. The nonsynonymous single nucleotide polymorphisms of DNA repair gene XRCC1 and susceptibility to the development of cervical carcinoma and high-risk human papillomavirus infection. Int J Gynecol Cancer. 2007 May-Jun;17(3):668-75. (7)Li X, Ye F, Chen H, Lu W, Wan X, Xie X. Human ovarian carcinoma cells generate CD4(+)CD25(+) regulatory T cells from peripheral CD4(+)CD25(-) T cells through secreting TGF-beta. Cancer Lett. 2007 Aug 8;253(1):144-53. (8)Zhou JH, Ye F, Chen HZ, Zhou CY, Lu WG, Xie X. Altered expression of cellular membrane molecules of HLA-DR, HLA-G and CD99 in cervical intraepithelial neoplasias and invasive squamous cell carcinoma. Life Sci. 2006 Apr 25;78(22):2643-9. Epub 2006 Jan 24. (9)Liu J, Ye F, Chen H, Lü W, Zhou C, Xie X. Expression of differentiation associated protein Hes1 and Hes5 in cervical squamous carcinoma and its precursors. Int J Gynecol Cancer. 2007 Nov-Dec;17(6):1293-9. (10)Hong D, Ye F, Chen H, Lü W, Cheng Q, Hu Y, Xie X. Distribution of human papillomavirus genotypes in the patients with cervical carcinoma and its precursors in Zhejiang Province, China. Int J Gynecol Cancer. 2007 Apr 26; (11)Chen H, Ye F, Zhang J, Lu W, Cheng Q, Xie X. Loss of OPCML expression and the correlation with CpG island methylation and LOH in ovarian serous carcinoma. Eur J Gynaecol Oncol. 2007;28(6):464-7. (12)Ma Y, Ye F, Lv W, Cheng Q, Chen H, Xie X. Correlation between soluble Fas level and apoptosis of T cells in ovarian carcinoma. Eur J Obstet Gynecol Reprod Biol. 2007 Sep 7; [Epub ahead of print] (13)Lu WG, Ye F, Shen YM, Fu YF, Chen HZ, Wan XY, Xie X. EMA-CO chemotherapy for high-risk gestational trophoblastic neoplasia: a clinical analysis of 54 patients. Int J Gynecol Cancer. 2007 Aug 17; [Epub ahead of print] (14)Chen, H; Ye, F; Zhang, J; Lu, W; Cheng, Q; Xie, X. Loss of OPCML expression and the correlation with CpG island methylation and LOH in ovarian serous carcinoma. Eur J Gynaecol Oncol. 2008; [Epub ahead of print] [主攻學(xué)科] 實(shí)驗(yàn)室 [研究方向] 婦科腫瘤、分子腫瘤學(xué)
臨床實(shí)驗(yàn)。?
